Since its inception 35 years ago, the biennial meeting of the European Society for Animal Cell Technology (ESACT) has built on a tradition of combining basic science and applications into industrial biotechnology to become the international reference event in its subject matter. Every other year, this gathering of academics and industry professionals features a famously exciting social program and an extensive vendor/supplier exhibition specific to animal cell technology. ESACT meetings are much-anticipated international venues for information exchange, inspiration, networking, and…
Manufacturing
Purifying Common Light-Chain Bispecific Antibodies
A bispecific antibody can bind two different antigens. Immunoglobulin G (IgG) type antibodies have two binding sites with different variable regions. An IgG variable region is made up of a variable light-chain sequence (VL) and a variable heavy-chain sequence (VH). The light chains (LCs) of common LC antibodies are identical for both variable regions, leaving the heavy chain (HC) for generating different specificities. Thus, recombinant host cells for production of common LC bispecific antibodies carry genes for both HCs, with…
High-Throughput Chromatography Screenings for Modulating Charge-Related Isoform Patterns
Monoclonal antibodies (MAbs) are an important class of biopharmaceuticals and are widely used to treat a variety of diseases such as cardiovascular diseases, cancer, and blood disorders. Antibodies are very complex proteins that show a high degree of microheterogeneities, including charge-, hydrophobicity- and size-related variances (1). Such variants can arise during any stage in a manufacturing process or storage as a result of enzymatic or nonenzymatic processes (2). Particular antibody variants that may affect the in vitro and in vivo…
Bioengineered Ears: The Latest Advance
Physicians at Weill Cornell Medical College (WCMC) and biomedical engineers at Cornell University have succeeded in building living facsimiles of human ears. They believe that their bioengineering method will finally achieve the goal of providing normal-appearing new ears to children born with a congenital ear deformity. The researchers used three-dimensional (3D) printing and injectable gels made of living cells. Over a three-month period, the ears steadily grew cartilage to replace the collagen used in molding them. The study’s colead-author is…
Are You Into Biosimilars?
Learn about GE Healthcare Life Sciences’ aim to help bioprocessing teams map out the optimal plan to transform a biosimilars project idea into result, with greater flexibility and confidence and with reduced time and cost.
Serum Free Culture of Mesencymal Stem Cells
This podcast features: Mark Rothenberg, PhD, Applications Manager, Corning Life Sciences [sc_embed_player_template1 fileurl=”http://commondatastorage.googleapis.com/bpidm/Cell%20Therapy/TASCAM_0057.mp3″] This podcast was recorded at the 2013 BioProcess Theater which took place at the 2013 BIO International Convention, April 22-25, 2013. The BioProcess Theater, a 50-seat amphitheater located on the exhibition floor at the heart of the BioProcess Zone, provided attendees with daily, complimentary opportunities to listen, learn, and interact with leading experts as they presented, discussed and debated the latest business and scientific trends…
In Silico and In Vitro tools for Accelerated Vaccine Design
This podcast features: Yvette Stallwood, PhD, Head of Applied Protein Services, Lonza Custom Manufacturing [sc_embed_player_template1 fileurl=”http://commondatastorage.googleapis.com/bpidm/Vaccines/TASCAM_0065.mp3″] This podcast was recorded at the 2013 BioProcess Theater which took place at the 2013 BIO International Convention, April 22-25, 2013. The BioProcess Theater, a 50-seat amphitheater located on the exhibition floor at the heart of the BioProcess Zone, provided attendees with daily, complimentary opportunities to listen, learn, and interact with leading experts as they presented, discussed and debated the latest business…
Five Traits of Successful Vaccine Development and Production
This podcast features: Dr. James Richardson, Advanced Bioscience Laboratories, Inc. [sc_embed_player_template1 fileurl=”http://commondatastorage.googleapis.com/bpidm/Vaccines/TASCAM_0067.mp3″] This podcast was recorded at the 2013 BioProcess Theater which took place at the 2013 BIO International Convention, April 22-25, 2013. The BioProcess Theater, a 50-seat amphitheater located on the exhibition floor at the heart of the BioProcess Zone, provided attendees with daily, complimentary opportunities to listen, learn, and interact with leading experts as they presented, discussed and debated the latest business and scientific trends impacting…
Development of Protein Capsular Matrix Vaccine (PCMV) Platform Technology
This podcast features: Kevin Killeen, Vice President Research. Matrivax Research and Development Corp. [sc_embed_player_template1 fileurl=”http://commondatastorage.googleapis.com/bpidm/Vaccines/TASCAM_0063.mp3″] This podcast was recorded at the 2013 BioProcess Theater which took place at the 2013 BIO International Convention, April 22-25, 2013. The BioProcess Theater, a 50-seat amphitheater located on the exhibition floor at the heart of the BioProcess Zone, provided attendees with daily, complimentary opportunities to listen, learn, and interact with leading experts as they presented, discussed and debated the latest business and…
cGMP Compliance Trends for Cellular Therapeutics and the Challenges in Late-Stage Commercial Ready Manufacturing
This podcast features: John Bermel, Director, Manufacturing Operations, WuXi AppTec [sc_embed_player_template1 fileurl=”http://commondatastorage.googleapis.com/bpidm/Cell%20Therapy/TASCAM_0058.mp3″] This podcast was recorded at the 2013 BioProcess Theater which took place at the 2013 BIO International Convention, April 22-25, 2013. The BioProcess Theater, a 50-seat amphitheater located on the exhibition floor at the heart of the BioProcess Zone, provided attendees with daily, complimentary opportunities to listen, learn, and interact with leading experts as they presented, discussed and debated the latest business and scientific trends impacting…