Gas filtration using sterilization-grade filters is a key part of the production, manufacturing and packaging process of biopharmaceuticals and other products. While it may seem a simple step, there are major safety considerations that have to be taken in to account to protect staff, equipment and facilities from hazard, particularly when working in high temperature and oxygen enrichment applications. This paper examines the safety issues involved, looks at material design considerations and introduces a ready-made solution for safe, effective, robust air/gas service filtration.