Chinese hamster ovary (CHO) cells are the expression system of choice for the manufacturing of biotherapeutics. They have the capacity to express a range of proteins such as therapeutic enzymes or monoclonal antibodies at multiple gram per liter titers.

As expression technologies have developed, obtaining such titers has been achieved mainly through improvements to media and feed. Similarly, the ability to identify high-productivity clones has been streamlined through the use of different selection systems, with metabolic selection being the preferred method in the bioprocess industry.

…Horizon was able to use its strong IP position to generate a CHO K1 GS knockout cell line with clear freedom to operate in biomanufacturing. Industry adoption has grown significantly with over 20 full commercial licenses currently in place and a strong pipeline of new licenses pending…

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