Countless factors influence a bioprocess, and measuring and evaluating them can be a major challenge. One of the most important performance parameters is the volumetric mass-transfer coefficient (kLa). ZETA has developed a reliable method for determining the kLa value and thus has revolutionized bioreactor design in plant engineering. With ZETA’s mass-transfer coefficient value determination system, measurements to determine kLa value can be taken at any point in a bioreactor, and based on such measurements, production conditions can be mapped perfectly.…
Author Archives: Thomas Maischberger
Improving Bioreactor Performance Measuring Dissolved Oxygen to Determine kLa
In recent years the biopharmaceutical industry has significantly increased the demands it makes on bioreactor systems. Efficient and reproducible production of active pharmaceuticals of high quality and in large quantities is of highest priority. However, bioprocessing is a complex topic. Numerous factors affect growth of cells in culture but are difficult to determine and interpret reliably. One of the most relevant performance parameters is the volumetric mass transfer coefficient (kLa). It describes the efficiency of gas transfer (e.g., oxygen) from…