Author Archives: Thomas Flouquet

Process Intensification and Continuous Bioprocessing: Multistep Multicolumn Chromatography (MS-MCC)

Until now, one chromatography system was needed to execute one chromatography step. With one three-module BioSC® system, three chromatography separations — including viral inactivation (VI) and in-line dilution (ILD) — can be operated simultaneously and continuously. This system is a straightforward switch from several batch skids to a single DSP skid (Figure 1). One skid performing an entire downstream process from capture to polishing can reduce a facility footprint drastically and decrease costs significantly. One key benefit of using this…