Author Archives: Serena Fries Smith

Medium and Feed Development: Beyond Maximizing Protein Titer to Optimizing Glycan Distribution and Simplifying Process Scale-Up

Serena Fries Smith, associate director of global technical engagements for Thermo Fisher Scientific, covered advantages in feed solutions in the context of current industry trends in an early November webinar. Leveraging feed designs and strategies can optimize glycosylation of complex proteins, simplify scale-up of fed-batch processes, and improve expression titers. Smith’s Presentation In 1994, the average expression titer was 0.5 g/L. Thanks in part to improvements in culture feeding, titers had increased to 1.3 g/L in 2004. By 2014, they…