Chromatogram review is a monitoring method used to verify process performance in packed-bed chromatography processes. By observing key process parameters such as chromatography column outlet conductivity or UV absorbance, it is possible to identify the signs of a poorly packed column, resin degradation, or equipment malfunction. Therefore, chromatogram review is implemented as an in-process control (IPC) to decrease variability and identify suboptimal performance, thereby enhancing yield and ensuring high product quality.   Fill out the form below to read the…