Author Archives: Luanfeng Li Ming Shi Yigao Song Lei Bao Wei Yang Xueting Zhang Min Ruan Gilbert Rishton Aziz Joudi Yuyang Teng Yan Xing Fulin Hu Xingnian Zhao Xiuqin Zhang Huicheng Li Guoqing Leng Shiping Yuan Qian Jia Matthew mizhou Hui

A Single-Use, Scalable Perfusion Bioreactor System

We have previously described a patented nonsparging, nonbubbling oxygen transfer method (1). This method is based on interaction between the air-exposed smooth surface of a bioreactor vessel and culture medium repeatedly sweeping across it with a certain force, which seems to generate microscopic bubbles among the water molecules (2). We manufactured high–oxygen-transfer Current suspension bioreactors with working volumes of 5 L, 50 L, 150 L, and 300 L. Here we describe the use of these suspension bioreactors as “artificial lungs”…