VTU Technology and Research Corporation Technologies (RCT) announced today that they have entered into a development and commercialization agreement for VTU to combine both companies´ Pichia pastoris protein production technologies. Pichia GlycoSwitch® – a new expression system for the production of glycoproteins with human-like glycosylation patterns- and VTU´s yield enhancing Pichia pastoris expression platform are now available in one package from VTU. This unique combination of technologies acting synergistically is of great benefit for customers as it leads to a…
Author Archives: BPI Contributor
A New Incompressible Protein A Resin to Improve Downstream Productivity in Single-Use Applications
This webcast features: Dr. Kiran Chodavarapu, Bioprocessing Business Development Manager at W.R. Grace. Implementation of single-use technologies and higher antibody titers upstream have put increasing pressure on downstream processes to improve efficiencies and keep pace with upstream advancements. There continues to be a lag in the development and adoption of single-use technologies in downstream – particularly in the area of chromatography. To help achieve the vision of a fully disposable and flexible manufacturing platform that addresses the current bottleneck in…
Vetter Announces Opening of Office to Support Growing Asian Healthcare Market
Vetter, a global leader in the aseptic fill and finish of injection systems, servicing the top-ten pharm/biotech companies worldwide along with mid-size firms and emerging startups, today announced the opening of a new representative office in Singapore. The announcement was made at a ceremony attended by members of local government agencies and a number of executives of pharmaceutical/biotech companies with a presence in the Asian region, as well as Vetter executives. The new office will allow Vetter to take better…
Patent Awarded to AdvantaPure®â€™s AdvantaPass™ Clean Room Wall Pass-Through System
AdvantaPure announces that U.S. patent 8,870,230 has been assigned to its AdvantaPass wall pass-through technology. Introduced earlier this year, AdvantaPass is used to transfer large volumes of fluids between clean rooms during pharmaceutical and biopharmaceutical production. The system maintains the separation of room atmospheres and minimizes cross contamination risks. AdvantaPass combines single-use tubing, connectors and seals with permanent, wall-mounted stainless steel components to eliminate cleaning validations associated with clean room protocols. It’s the first system of its kind to provide…
New Flexsafe Bag Family: Combining Material Science, Film Expertise and QbD for Reliable and Consistent Cell Growth
The technical and economic benefits of single-use are well known and the bio-manufacturing industry is broadening their adoption in all steps of commercial production. This poster reviews the challenge of poor or inconsistent cell growth associated with the use of single-use bags for media storage and cell culture and how the solutions offered with the new Flexsafe bag family meet these new requirements. The poster introduces a new product development and supply chain management strategy that involves the use of…
Lonza and Celladon Corporation Establish a Strategic Commercial Manufacturing Collaboration for MYDICAR®
Lonza, a global leader in the field of viral therapy and biologics manufacturing, and Celladon Corporation (NASDAQ: CLDN), a biotechnology industry leader in the field of cardiovascular gene therapy, announced today that they have entered into an agreement providing for the future commercial production of MYDICAR® (AAV1/SERCA2a), Celladon’s enzyme replacement therapy for advanced heart failure that is currently in Phase 2b clinical development. This agreement follows a successful multi-year clinical manufacturing relationship and provides for initiation of pre-construction activities and…
Bristol-Myers Squibb and Lonza Expand Manufacturing Agreement
Bristol-Myers Squibb Company (NYSE: BMY) and Lonza today announced a multi-year expansion of their existing biologics manufacturing agreement. The contract expansion will include the production of commercial quantities of a second Bristol-Myers Squibb biologic medicine at Lonza’s mammalian manufacturing facility in Portsmouth, New Hampshire. Financial terms were not disclosed. Biologic medicines that treat serious diseases are an integral part of Bristol-Myers Squibb’s specialty care portfolio and R&D pipeline. Bristol-Myers Squibb and Lonza have been collaborating since 2003 to produce commercial…
Sartorius Opens New Application Center in Shanghai
Sartorius, a leading international laboratory and pharmaceutical equipment supplier, officially opened a new application center at its Shanghai office last week. Among the guests, representatives from the Shanghai government, customers from the biopharmaceutical industry as well as business partners and the media attended the opening ceremony. With a floor space of 240 square meters, or 2600 square feet, the new application center offers ample room for product demonstrations, trial runs and training sessions. At this center, customers from the biopharmaceutical industry…
Optimization of HEK 293 and CHO Cell Culture Media Supplementation by DoE Methodology
This webcast features: Dr. Francesc Gòdia, Professor of Chemical Engineering at Universitat Autònoma de Barcelona Chemically defined and animal derived free components media are required for bioprocess development and operation using mammalian cell as platform for the production of biopharmaceuticals. The supplementation of commercial chemically-defined media with specific compounds is studied for the optimization of CHO and HEK 293 cell culture. Design of Experiments approach is used to first screen the most efficient compounds and further determine their optimal conditions.…
EMD Millipore Introduces Three New Resins for its Chromabolt® Prepacked Chromatography Columns
EMD Millipore, the life science division of Merck KGaA of Darmstadt, Germany, announces the availability of three new chromatography resins for its Chromabolt® prepacked columns. These pre-validated chromatography columns can come packed with either strong cation exchangers, weak cation exchangers or strong anion exchangers, freeing up end users’ time and resources by eliminating manual column packing and cleaning. Designed for pilot and early clinical manufacturing, the Chromabolt® columns are now available packed with the following resins: Strong cation exchanger Fractogel®…