Stem Cell Harvesting Product: CellCelector stem cell picker Applications: Stem cell projects Features: Through its distribution agreement with AVISO GmbH, TAP offers the CellCelector automated stem cell picker to the US, Canadian, Irish, and UK markets. The noninvasive system automates selection and harvesting of murine and human stem cells to reduce associated time and costs in research and development. Lifelike images of cells before harvest allow users to document and standardize the quality of cells chosen. The system compliments TAP’s…
Author Archives: BPI Contributor
IBC’s Seventh Annual Single-Use Applications for Biopharmaceutical Manufacturing
Many companies are adopting single-use technologies. This program begins with a workshop that showcases the cutting-edge implementation experience of CMOs and start-up companies. The complete program includes the latest case studies and strategies for single-use bioprocessing, including development of a fully disposable downstream train, disposable bioreactors and sensors, and other components. Validation for applications involving the reduction of extractables, leachables, endotoxins, particles, and other risk factors will be explained. A shared session with the colocated vaccine conference gives an in-depth…
Improving IEX Throughput and Performance with Differentiated Chromatography Sorbents
As upstream processing becomes more optimized, it increases the amount of impurity and contaminants to be removed from large volumes of feedstock. With this added pressure on downstream processing, there is a pressing need for more efficient chromatography operations.
In this paper, the authors describe how they characterized differentiated selectivity of Q and S HyperCel ion-exchange sorbents. They evaluated the dynamic binding capacity in various pH, conductivity, and residence time conditions; carried out a separation of a model mixture to further characterize the sorbents’ specific selectivity; and report on a real case application in which one was used in a capture step for purification of a recombinant protein from an E. coli lysate.
Potelligent® CHOK1SV: The Evolution of the GS Gene Expression System™
Lonza and BioWa have combined their technologies to produce a new host cell line, Potelligent® CHOK1SV. This new cell line merges the benefits of Lonza’s GS Gene Expression SystemTM with those of BioWa’s POTELLIGENT® technology. Recombinant cell lines created using this new and improved host cell line have shown:
• Enhanced ADCC
• Growth suitable for a production process
• High product concentration levels in a platform process
• Ability to work seamlessly with current manufacturing processes
Join Allison Porter of Lonza Biologics as she provides a detailed look at the two technologies separately and the performance of the new Potelligent® GS-CHO technology.
Improving Downstream Processing Using Membrane Chromatography
The chromatographer is faced with a variety of anion and cation exchange phases that include a limited range of functional groups. These groups are attached to a wider range of base matrices, such as sorbents for column applications, monoliths and membranes. When ion-exchange membranes are used in chromatography devices, they demonstrate very high usable flow rates with enhanced throughput. Additionally the pre-packed format of these columns enables ease of use and unit-to-unit consistency. It also allows for a disposable chromatographic processes that eliminates costly and time-consuming cleaning validation.
During this on-demand webcast, diverse case studies will be presented that feature applications ranging from contaminant clearance to capture of target molecules in downstream purification processes. These studies highlight scalability, fast and efficient capture of large molecules, and improved process economics. When used in these applications, ion-exchange membranes proved a demonstrable alternative to packed bed chromatography and is better suited for subsequent purification processes..
Join Ajay R. Lajmi of Pall Life Sciences as he takes an in-depth look at the trends and challenges facing downstream processing and illustrates the benefits of membrane chromatography vs. resin chromatography.
Anatomy of a Single-Use Bioreactor Deployment
Rapid commissioning and start-up enabled by system design and process support
Deploying a new GMP single-use bioreactor requires the careful coordination of hardware, software, disposable components, process engineering, tech-transfer and other disciplines. When time pressure is involved as it often is in the current business environment, the task of mastering an unfamiliar piece of process equipment can provide a challenge to biopharm organizations. Recognizing this, Xcellerex has designed the XDR single-use bioreactor as a fully-integrated system that is engineered for rapid delivery and start-up, capable of going from order to delivery to working process in just 12-16 weeks. Further, the Xcellerex team uses XDR reactors every day in our own GMP operations, allowing our technical team to provide fully informed support to customers. This webinar provides an overview of XDR deployment capabilities, and shares a recent customer case history of a successful rapid XDR deployment.
Global Marketplace
Small-Scale Fluid Control Product: Flipper 6650 solenoid valve Applications: Analytical fluid dosing Features: With a pitch of only 4.5 mm, the Flipper 6650 solenoid valve comes in 2/2- and 3/2-way versions that offer performance comparable to 10-mm and 16-mm valves. The media-separated valve is compact and fast-switching, optimized especially for reproducible and precise dosing of aggressive fluids. Because of its compact size, the valve requires smaller internal volume in the connecting plates, thus increasing efficiency of…
Cell Line Development and Engineering Novel Approaches to Improve Speed of Development, Stability, Manufacturability, Quality, and Fundamental Understanding
I BC’s sixth annual Cell Line Development and Engineering conference will deliver 37 presentations in a three-day, single-track format for the most valuable and intensive learning experience you can attend. This program has earned its reputation by attracting thought leaders in industry and academia to collectively examine and provide solutions to the industry’s most daunting challenges. For 2010, we developed an agenda that will help you achieve your ultimate goal of improving quality and understanding of your cell lines while…
Global Marketplace
Laboratory Instruments Product: Cubis laboratory balance and Arium Pro laboratory water purification system Applications: Precision medical and life-science laboratory work Features: International Forum Design GmbH awarded Sartorius the 2010 international iF Product Design Award for two laboratory products in the medicine/healthcare category. Cubis modular laboratory balances can be custom-configured for different working environments. The Arium Pro laboratory water purification system produces ultrapure water quickly, safely, and cost-effectively for chromatography, cell cultivation, and protein purification laboratory applications. Contact Sartorius AG www.sartorius.com…
TIDES® Oligonucleotide and Peptide Technology and Product Development
Moving to Boston, MA, after four years in the western United States (Las Vegas and Carlsbad, CA), the Tides conference continues to be the must-attend event for the industry that grows in attendance each year. The 2010 agenda includes thought-provoking keynotes and featured presentations, a compelling regulatory session, and discussions with CBER, FDA, and European regulatory agency speakers. In separate tracks for each type of molecule, learn more from the new, full-day sessions on CMC manufacturing and analysis and a…