Author Archives: BPI Contributor

Culture of Normal Human Dermal Fibroblast Cells in a Functionally Closed Automated Cell Expansion System

by

The Quantum Cell Expansion System is a functionally closed and automated hollow-fiber bioreactor system that is designed to expand both adherent and suspension cells in a reproducible manner. The hollow-fiber membrane requires a coating agent to help facilitate cellular adherence when culturing an adherent cell type such as MSCs. Pooled human cryoprecipitate (CPPT, Bonfils Blood Center) was examined as an alternative to FN because it is a rich source of extracellular matrix components, including fibrinogen (Freedman, 2010), and also because…

November 2, 2012

A New Mixed-Mode Resin for Large Scale Biomolecule Purification

by

Chromatographic resins with high capacities and selectivities differing from those seen with traditional hydrophobic interaction and ion exchange media are now in demand. Mixed-mode chromatography media is an alternative. Some mixed-mode resins combine both traditional hydrophobic interaction and ion exchange media. This poster introduces TOYOPEARL® MX-Trp-650M, a high-capacity weak cation mixed-mode resin for the purification of biomolecules. The polymethacrylic base bead was chemically modified with the amino acid tryptophan which combines a weak cationic group with a hydrophobic functional group.…

November 2, 2012

Global Marketplace

by

Single-Use Technology Product: inSITE inflation and integrity testing system Applications: Media/buffer preparation, filtration, separations, seed/culture harvest, ultrafiltration, final filling Features: ASI’s inSITE system applies a final integrity test at the point of use to eliminate concerns for gross and fine leaks that can come from handling and loading procedures. The unit will inflate to a specified pressure to limit errors from pinching and creasing. It can be used with any container ≤3,000 L and is completely mobile with cleanroom-grade wheels…

November 1, 2012

IBC’s Fifth Annual AsiaTIDES

by

This is the only event in Japan with coverage of all oligonucleotide classes: RNAi, peptide therapeutics, and vaccines. AsiaTIDES continues to be the premier forum where attendees get a comprehensive update, meet key players, and increase their knowledge of the oligonucleotide- and peptide-based therapeutics fields. Hear the latest reports from RXi, Tekmira, Santaris, miRagen, Arrowhead, REPLICor, Noxxon, Silence, PeptiDream, Pfizer, Immunovaccine, OncoTherapy Science, Zealand, Radius, Aileron, and more. Learn manufacturing capabilities of all the major oligonucleotide and peptide contract manufacturing…

November 1, 2012

Global Marketplace

by

3D Bioreactor Product: InBreath whole-organ bioreactor Applications: Tissue engineering and regenerative medicine for trachea, esophagus, intestines, blood vessels, and other hollow, tubular organs Features: The autoclavable, GLP-compatible InBreath bioreactor is designed for cell seeding and culturing on intraluminal and extraluminal surfaces of a tubular matrix. A polymer culture chamber houses the scaffold and culture medium for the entire duration of organ generation. Secondary “paddle” elements move with the scaffold holder to mix the culture medium continuously for mass transport and…

October 1, 2012

IBC’s Inaugural Drug Product Quality Summit

by

The vast majority of drug shortages — 82% of the 168 products in short supply — are sterile injectables. According to an IMS Institute for Healthcare Informatics report from November 2011, many are linked to fill– finish deficiencies. In addition to supply shortages, medicines can be delayed in reaching patients due to contaminated raw materials, findings of particulates, extractables and leachables, vial stopper and glass problems or interactions with product, and even cross contamination. IBC’s Drug Product Quality Summit is…

October 1, 2012

Cell Therapies Roundtable: Building the Pillars to Success

by

In order to deliver cell-based therapies on a commercial scale, cell therapy companies and suppliers must form partnerships in order to overcome existing manufacturing, regulatory, and analytical challenges. Four leading cell therapy experts discuss what is and what has to be done in order to accomplish this objective.

September 1, 2012

Moving Cell Purification Methods from Bench to Bedside

by

The technological innovations and improvements to cell purification and other cellular analysis-based processes have dramatically increased sample throughput rates resulting in an improved ability to treat cancer, autoimmune diseases, and a range of applications in regenerative medicine.

September 1, 2012