Today’s bioprocessing technicians are highly skilled professionals who can operate large automated equipment, juggle numerous support activities, and document manufacturing deviations. In coming years, their jobs will become even more rigorous as companies push more decision-making to the production floor to save time and resources. With the trend toward smaller batches made in bench-scale and/or single-use equipment, this strategy becomes easier to implement. One way to foster improved decision-making on the production floor is to hire or promote employees who…
Friday, October 20, 2017 Daily Archives
Addressing Knowledge Gaps and Skills Development: Modular Training Keeps the Bioindustry at the Leading Edge
One major challenge facing the global bioindustry today is finding talented individuals to work in the type of highly skilled interdisciplinary environments necessary for effective bioprocess development. Ideally, such individuals require a combination of technical knowledge and expertise spanning biological sciences, physical sciences, mathematics, and engineering. Numerous industry surveys have repeatedly stressed the lack of suitably trained individuals equipped with necessary skills to work at the biology−engineering interface to meet the growing and changing demands of industry. The challenge is…
Hands-On Training for Biopharmaceutical Careers: Trainees Gain Practical Experience in Realistic Production Environments
At the April meeting of the BPI International Summit (25−26 April 2017) delegates were treated to a tour of a new training facility. The Biotech Training Facility is about a 20-minute drive from the Amsterdam airport and located in the Leiden Bioscience Park. The park houses companies that employ ~18,000 life science workers. In addition, the Leiden University and the Leiden Academic Medical Center complement the dynamic high-tech environment that facilitates establishment of such a knowledge and experience center as…
Introducing NIIMBL: Accelerating Innovation in Biopharmaceutical Manufacturing
The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) was launched in March 2017 as a cooperative agreement with the National Institute for Standards and Technology (NIST), part of the US Department of Commerce. NIIMBL is one of the newest members of Manufacturing USA, a network of manufacturing innovation institutes through which industry, academia, and government work together to accelerate implementation of advanced manufacturing and develop a trained workforce in several key sectors of ththe US economy. NIIMBL’s mission is…
Targeted Locus Amplification for Transgene Sequencing in rCHO Clones Expressing Therapeutic Lysosomal Enzyme
This webcast features: Vishal Agrawal, PhD, Scientist II, Cell and Molecular Biology, Biomarin Pharmaceutical Inc. and Joseph Abad, Field Applications Scientist, MaxCyte. Transgene site of integration dictates clonal stability and the long term transcriptional activity of gene of interest in recombinant CHO cells. In this presentation, we will discuss the application of targeted locus amplification (TLA) technology to identify genomic sites of transgene integration and integrity of transgene sequence itself to assess the suitability of recombinant CHO clones as a…