Strong anion exchange (Q) chromatography is an industry standard for polishing purification steps of mAb production. It is a proven technology which removes viruses, and host cell proteins from process feed streams in flow through mode.

NatriFlo HD-Q devices adsorbers feature a hydrogel membrane which combines high dynamic binding capacity and salt tolerance to deliver best-inclass performance. This makes it possible to rapidly process large sample volumes using a small disposable device.

This article examines the ability of NatriFlo HD-Q adsorbers to clear virus and host cell proteins (HCP) from partially purified (post-Protein A) MAb solutions with high productivity (6 second residence time vs. 2-5 minutes for traditional columns).