Single-use technology (SUT) has long been viewed as a viable solution to today’s biopharmaceutical manufacturing challenges. It offers the flexibility to change a production configuration to meet demand while also offering many other cost benefits, such as savings related to the elimination of clean-in-place (CIP) and sterilization-in-place (SIP) processes. However, traditional and fed-batch models fail when trying to adapt to single-use flexibility due to the required rewriting of code and revalidation. The best way to use the flexibility of single-use is to pair it with a modular automation system in a continuous processing configuration. This setup eliminates the limitations and burdens of manual control while optimizing the throughput from upstream to downstream. Through the application of technology available today, manufacturers can reap the significant cost savings provided by a continuous processing strategy while also applying the controls necessary to successfully monitor and control it.