BrainStorm Cell Therapeutics is eying the potential launch of NurOwn and has selected CDMO Catalent to produce the autologous cell therapy from its site in Texas. Known as NurOwn, MSC-NTF is cell therapy candidate being investigated in Phase III trials for Amyotrophic Lateral Sclerosis (ALS) by BrainStorm. The potential therapy is made from bone marrow-derived mesenchymal stem cells (MSCs) taken from the patient, which are expanded and differentiated ex vivo before being converted into MSC-NTF cells that secrete high levels…
Deal-Making
Resilience buys cell free synthesis tech firm SwiftScale Biologics
Resilience has bought cell-free protein synthesis tech firm SwiftScale Biologics in a deal designed to support novel therapeutic research. The San Diego based contractor – officially called National Resilience – announced the acquisition late last week, citing growing biopharmaceutical industry interest in cell-free protein synthesis as the prompt for the deal. Resilience CEO Rahul Singhvi suggested the approach could help industry overcome some of the hurdles that complicate commercial manufacture and scale-up. “Biologics production today is limited to what can…
Downstream dealmaking: Donaldson buys Solaris, Ecolab closes on Purolite
Filtration firm Donaldson Company has acquired Solaris Biotechnology to bolster its presence in the life sciences space. Meanwhile, Ecolab has completed the $3.7 billion acquisition of purification firm Purolite. Minneapolis-based filtration firm Donaldson will add a range of bioreactors, fermenters, and tangential flow filtration systems through the €41 million ($47 million) addition of Italy’s Solaris. “This acquisition is an important step on our journey towards strengthening our presence in the life sciences market,†said Tod Carpenter, CEO of Donaldson. “With…
Sanofi boosts vaccine pipeline with Origimm buy
Sanofi will add a potential acne vaccine candidate to its pipeline through the acquisition of Origimm Biotechnology. Sanofi is set to acquire Austrian biotechnology firm Origimm, which specializes in the discovery of virulent skin microbiome components and antigens causing skin diseases for an undisclosed fee. The move sees the French pharma giant  add a potential first-in-class vaccine candidate ORI-001 to treat acne vulgaris, a stigmatizing skin condition that affects millions of people of different ages worldwide. ORI-001 is a therapeutic…
CDMO round-up: Lonza, Abzena, and Samsung deals
BlueJay Therapeutics selects Lonza to manufacture its HBV antibody candidate; BiVictriX contracts Abzena; Samsung Biologics will manufacture drug substance for GreenLight’s mRNA COVID-19 vaccine candidate. Great to have you here for BioProcess Insider’s CDMO round-up. First up in our contract development manufacturing organization (CDMO) round-up is Swiss company Lonza, which BlueJay Therapeutics recently selected to provide a tailored program to support production of BJT-778 a monoclonal antibody (mAb) drug candidate targeting chronic hepatitis B virus (HBV) infection. Under terms of…
Generate Biomedicines raises $370m to advance AI drug discovery tech
Generate Biomedicines has raised $370 million to further develop its artificial intelligence (AI) drug discovery technology, expand its team and build labs. The Cambridge, Massachusetts biotech completed a series B round last week, attracting investment from founding backer Flagship Pioneering and the Abu Dhabi Investment Authority (ADIA), the Alaska Permanent Fund and Altitude Life Science Ventures. Generate said the money will allow it to “advance and evolve†the platform and “scale the organization with top-tier scientific and computational talent.†It…
Ins & Outs: Filling gaps at Pfizer and the FDA
Pfizer’s chief financial officer Frank D’Amelio will retire from his position after 15 years at the firm, prompting an external search for his successor. Meanwhile, Joe Biden nominates Robert Califf for US FDA chief. Sit back, relax, and enjoy this week’s Ins &Outs. Pfizer announced D’Amelio’s planned departure from the company and stated he has agreed to stay on board in a consulting role while the firm externally search for a chief financial officer (CFO). Pfizer claim that during D’Amelio’s…
Novo Nordisk to add RNAi engine in $3.3bn Dicerna buy
The acquisition of development partner Dicerna Pharmaceuticals will accelerate Novo Nordisk’s position in the RNA interference (RNAi) space. In 2019, Novo Nordisk paid $175 million upfront to collaborate with Dicerna in the discovery and development of RNAi therapies for liver-related cardiometabolic diseases using Dicerna’s proprietary GalXC RNAi platform technology. Two years on, and the Danish drugmaker has entered an agreement to buy the partner outright, offering $38.25 per share and valuing the firm at around $3.3 billion. “The acquisition of…
Inceptor snaps up Arranta plant in Florida
Inceptor Bio has acquired a clinical manufacturing plant in Gainesville from Arranta Bio to support trials of its cell therapy pipeline. The 29,000 square-foot facility will be used as a base for Inceptor’s Advanced Manufacturing Platform (AMP), a scalable shared production infrastructure used to produce a pipeline of cell therapy candidates for the firm and its subsidiaries. “We are thrilled to welcome the experienced, talented operating team from Arranta and look forward to establishing cell therapy GMP clinical manufacturing as…
CGT Catapult partners to overcome barriers in ATMP industry
CGT Catapult has partnered with Deep Science Ventures to tackle issues and create companies that address needs in the advanced therapy sector. Together, the Cell and Gene Therapy Catapult (CGT Catapult) and London , UK-based venture creator Deep Science Ventures (DSV) aim to drive innovation and employment opportunities in the advanced therapy industry by addressing challenges in the sector and creating companies to support better patient outcomes. “The CGT Catapult will leverage its world-class technical and regulatory expertise in ATMPs alongside…