Resilience will acquire Bluebird’s North Carolina lentiviral vector manufacturing facility for $110 million, kickstarting an alliance to drive R&D and cell therapy production. Under the terms of the deal, Resilience will acquire Bluebird’s 125,000 square-foot manufacturing plant in Durham, North Carolina, which it only opened two years ago after acquiring the facility in November 2017 and investing $80 million in the site. Bluebird will receive the $110 million upfront and have preferred lentiviral vector (LVV) production access. The firm claims…
Deal-Making
Belgian Biotechs unite to manufacture llama-based COVID antibodies
Mithra Pharmaceuticals will provide fill-finish services for ExeVir, which is developing a llama-derived antibody therapy to treat and prevent COVID-19. The deal, of which no financial details have been disclosed, will see contract development manufacturing organization (CDMO) Mithra utilize its fill-finish capabilities for ExeVir’s candidate, XVR011. XVR011 is a single domain-based anti-COVID-19 antibody. It is derived from llama antibodies, which are smaller than human antibodies and therefore can attach to parts of a virus that are hard to access for…
PerkinElmer continues M&A path with $5.25bn BioLegend deal
PerkinElmer is set to add antibody and reagent supplier BioLegend in a deal that analysts say could transform its Discovery and Analytical Solutions (DAS) business into a high growth segment. The acquisition announced yesterday and expected to close by the end of the year will see life sciences giant PerkinElmer pay $5.25 billion – including $2.2 billion in stock consideration – for private antibody and reagent developer BioLegend. The proposed deal xpands PerkinElmer into the “fast growing, high margin, antibody…
Samsung Biologics to manufacture Kineta’s antibody immunotherapy
Korean CDMO Samsung Biologics will develop and provide manufacturing services to support IND filing for Kineta’s anti-VISTA antibody candidate. Contract development manufacturing organization (CDMO) Samsung Biologics has signed a partnership agreement to provide end-to-end services for Kineta’s anti-V-domain immunoglobulin suppressor of T cell activation (anti-VISTA) candidate KVA12.1, which aims to treat solid tumors. Preclinical studies have shown KVA12.1 to have single agent anti-tumor activity and that targeting VISTA along with programmed cell death-1 (PD-1), PD ligand 1 (PD-L1), or cytotoxic…
Second Bluebird gene therapy approval a boon for Minaris
CDMO Minaris says it will be the commercial manufacturer for Skysona (elivaldogene autotemcel, Lenti-D), a second Bluebird Bio gene therapy approved by the European Commission. The European Commission (EC) granted marketing authorization of Skysona for the treatment of early cerebral adrenoleukodystrophy (CALD) yesterday. The one-time gene therapy uses a patient’s own hematopoietic stem cells (HSC) to treat the underlying cause of the neurologic condition CALD. SKYSONA uses ex vivo transduction with the Lenti-D lentiviral vector (LVV) to add functional copies…
BioNTech adds Kite’s T cell platform and production facility
BioNTech ups its production capacity to support cell therapy clinical trials by acquiring Kite’s R&D platform and gaining a facility in Gaithersburg, Maryland. The deal, of which financial details have not been disclosed, sees BioNTech acquire Gilead Sciences’ Kite Pharma’s solid tumor neoantigen T cell receptor (TCR) R&D technology. The deal will also see BioNTech take over the lease at the Gaithersburg manufacturing facility. BioNTech became a household name after BNT162b2 became the first messenger RNA (mRNA) COVID-19 vaccine to…
Forge Bio wins GentiBio AAV vector contract
Forge Bio will develop and manufacture adeno-associated viral (AAV) vectors for GentiBio’s engineered Tregs candidates from its site in Columbus, Ohio. The deal will see contract development and manufacturing organization (CDMO) Forge Bio use its Blaze Vector production platform and HEK 293 Suspension Ignition Cells to support GentiBio’s preclinical and clinical programs. The work will be undertaken at Forge Bio’s facilities at The Hearth, Columbus, which has grown through heavy investment over the past year. “Forge has rapidly expanded our…
Rebranded AMRI on spending spree with LakePharma and Integrity buys
A new name, the purchase of biomanufacturer LakePharma, and the addition of fill-finish firm Integrity Bio. All in a week’s work for Curia, the CDMO previously known as AMRI. Contract development and manufacturing organization (CDMO) AMRI rebranded itself this week as Curia before announcing a double acquisition expected to boost its capacity and capabilities in the manufacturing services space. The first deal sees the CDMO acquire Integrity Bio, a privately held formulation and fill-finish organization headquartered in Camarillo, California. Financials…
Poseida joins Cellares’ early-access cell therapy tech program
Cellares Corporation has added a third firm to its early-stage partnership program, giving Poseida Therapeutics access to its closed and automated cell therapy manufacturing platform. Californian firm Cellares is looking to overcome limitations in current advanced therapy manufacturing through the development of its manufacturing platform, the Cell Shuttle. The Cell Shuttle is a modular and automated solution comprising hardware, software, robotics and consumables and according to the firm is capable of producing 10 patient doses simultaneously. Since 2020, the firm…
Selexis and KBI to advance Immatics program towards IND
Selexis and KBI will provide integrated services to develop Immatics’ bispecific T cell engaging receptor program. Selexis will leverage its SUREtechnology to produce a clonal cell line for Immatics’ candidate IMA402 and KBI Biopharma will utilize its formulation, analytics, and manufacturing capabilities. No financial details have been disclosed. “Selexis and KBI are both JSR Life Sciences companies and are able offer partners integrated services that can accelerate biologic development timelines,†CEO of both companies Dirk Lange told BioProcess Insider. “These…