Author Archives: BPI Contributor

Collaborate to Innovate: A Webinar Series

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As a senior leader in pharmaceutical development and manufacturing, you know that keeping up-to-date on industry trends is critical to maintaining competitive edge. But do you know how to actively drive these trends and apply them to your manufacturing processes? Are you collaborating with the right stakeholders in order to expand your capabilities and bring your innovation strategy to life? In this webinar series, three subject matter experts will share their perspective on the future of the industry and provide…

June 28, 2017

Quattroflowâ„¢ Launches EZ-Set Pump Chamber Replacing System for Single-Use Pumps

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Quattroflowâ„¢, part of PSG®, a Dover company and a leading brand of positive displacement quaternary diaphragm pumps, is pleased to announce the launch of the EZ-Set Pump Chamber Replacing System for its Single-Use pumps. With EZ-Set, users can replace a Single-Use pump chamber in 30 seconds by hand without the use of special tools or torque wrenches. It’s quick, it’s easy, and it’s safe. The comfortable handgrip design of the EZ-Set makes replacing the pump chamber so easy you can…

June 27, 2017

Selexis Announces Commercial License Agreement with Takeda for the Development of Fusion Proteins

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Selexis SA, a pioneering life sciences company and a global leader in mammalian cell line generation technology, announced today that it has entered a commercial license agreement (CLA) that provides Takeda Pharmaceutical Company Limited [TSE:4502], (“Takedaâ€) with access to high-performance research cell banks (RCBs) developed using the Selexis SUREtechnology Platformâ„¢. Takeda is leveraging Selexis’ mammalian cell line-based protein expression platform to develop recombinant fusion proteins. “Successfully developing a high-performance cell line expressing Takeda’s fusion proteins validates the strength of our…

June 27, 2017

Buffer Selection in Biologics Manufacturing

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They’re far less exciting than the life-changing treatments they help create, but buffers play a critical role in upstream and downstream biomanufacturing processes. ANGUS takes you backstage with “Buffers in Biologics Manufacturing” – an in-depth article co-authored by Dr. Dave Green, Vice President of R&D, ANGUS, that explores the important variables to consider when selecting the right buffer (and buffer supplier). And, when it comes to biomanufacturing, we know a thing or two about buffers. Why? Because we invented them.…

June 27, 2017

Sartorius Stedim Biotech introduces Sartobind® Cassettes

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Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry, has expanded its range of single-use membrane chromatography solutions with Sartobind® Cassettes. This convenient, pod-like modular system has been developed for commercial applications in both capture and polishing. New Sartobind® cassettes offer the same flow path, bed heights (4 and 8 mm) and void volume ratios as Sartobind® capsules, and are compatible with Q, S, STIC PA and phenyl ligands. The new design goes beyond the previous 5…

June 23, 2017

Insulin Improves Cell Growth and Influenza Yield in a HEK293 Suspension Cell Line

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This webcast features: Aziza Manceur, Research Officer, National Research Council Canada To produce large quantities of vaccines in a rapid and cost-effective way is the main challenge that the vaccine industry is facing. Major changes to current bioprocesses are difficult to implement due to costs associated with the regulatory approval process. Therefore, we propose to use insulin, a protein currently used and approved in several processes and production platforms, as an additive to boost cell growth and viral production. The HEK293SF-3F6 cell…

June 22, 2017

Continuous Capture Chromatography, A simple, Robust Approach to Move From Batch to Continuous Capture

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Increasing demands for the production of biopharmaceuticals, such as monoclonal antibodies (mAbs), vaccines and recombinant proteins, require new, innovative purification approaches with higher efficiency and productivity while maintaining or reducing costs. One of these approaches is continuous capture chromatography. Continuous capture chromatography, also known as CaptureSMB was developed by ChromaCon AG. CaptureSMB is a 2-column periodic counter current chromatography (2-PCC) process where the first column is fully loaded and breaks through to the second column. The first column is eluted…

June 21, 2017

Gram Scale Transient Antibody Production and Stable Cell Line Generation Using Flow Electroporationâ„¢ Technology

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In recent years researchers have turned to transient gene expression (TGE) as an alternative to CHO stable cell line production for early stage antibody development. Despite advances in transfection methods and culture optimization, the majority of CHO-based TGE systems produce insufficient antibody titers (low mg/L level) for full use within the biotherapeutic development pipelines. MaxCyte’s delivery platform for cell engineering is based on Flow Electroporationâ„¢ technology and provides a universal means of fully scalable, highly efficient CHO-based TGE for the…

June 17, 2017

Single-Use Technology: The Next 5 Challenges to Conquer

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Now that single-use technology plays a part in nearly all bio-production processes, what is next? Several challenges remain that are still serious enough to delay or even stop the use of single-use technology, which in turn can extend the time to market and increase the cost of lifesaving biopharmaceutical products. Of the existing difficulties, which five are the most critical? This paper considers five existing challenges in the implementation of single-use technology including scale, automation, product compatibility and compliance, speed…

June 15, 2017

KBI Biopharma Acquires Alliance Protein Laboratories, Expands Biophysical Characterization Capabilities

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KBI Biopharma, Inc. (KBI) has agreed to acquire the assets of San Diego-based Alliance Protein Laboratories (Alliance), a leading analytical services company specializing in biophysical characterization of biopharmaceuticals. Founded in 1998, Alliance is well known and highly regarded around the world for its expertise in characterization of therapeutic proteins, peptides, nucleic acids and vaccines. Recognized as the foremost expert in analytical ultracentrifugation (AUC), an essential technology for determining physical stability, association state, molecular weight and quantitative characterization of protein aggregates,…

June 15, 2017