Author Archives: Dan Stanton

Affinity resins: Avitide gears up to support COVID-19 vaccine makers

Avitide says a specific SARS-CoV-2 virus spike protein affinity resin greatly helps the current COVID-19 efforts and could greatly accelerate the speed of response in future pandemics. Bioprocess service and consumable firms are looking to support the next wave of COVID-19 vaccines as they progress through the clinic. Last week, we reported that Repligen and Navigo launched an affinity resin specifically for the purification of COVID-19 vaccines. But they are not alone, and New Hampshire-based firm Avitide recently finalized its…

Resilience bags Sanofi-Genzyme plant in Boston

Newly formed CDMO Resilience takes over the once-troubled Allston facility in Massachusetts from Sanofi, retaining all 250 staff. Last November, ‘National Resilience’ – less formerly known as Resilience – raised over $800 million in funding and launched itself as a contract development and manufacturing organization (CDMO). At the time, the firm said it will provide “new, better, faster ways†to manufacture cell and gene therapies and alluded to having capacity at multiple facilities to carry out this mission. Now the…

Vigene upping viral vector capacity by 50% through Maryland facility

CDMO Vigene Biosciences has leased a 52,000 square foot facility in Maryland to support ongoing demand for viral vectors. The contract development and manufacturing organization (CDMO) has entered a lease agreement, adding a facility in Rockville, Maryland with supporting infrastructure, including HVAC and flooring and Water for injection (WFI) system in place The additional manufacturing space will complement Vigene’s nearby GMP manufacturing plant, acquired in 2016 through the purchase of assets from Omnia Biologics. The lease brings Vigene’s total lab…

Rentschler catapults into the cell and gene therapy space through UK investment

German CDMO Rentschler will set up manufacturing capabilities at the UK’s Cell and Gene Therapy (CGT) Catapult, launching itself into the regenerative medicine space. Family-owned contract development and manufacturing organization (CDMO) Rentschler offers mammalian manufacturing and fill and finish services for biologics but has now expanded into cell and gene therapy production through a deal with the CGT Catapult, based in Stevenage, UK. Rentschler will establish its manufacturing capabilities – including adeno-associated virus (AAV) vector production – through “a significant…

Podcast: Industry veteran moves to Lykan Bioscience, and this time its personal!

In the latest episode of the BioProcess Insider Expression Platform, we explore the evolution of cell and gene therapy production with new COO of Lykan Bioscience, Patrick Lucy. From Repligen, to Lonza, to Pfenex, Patrick Lucy has had an illustrious career. His latest career move is to Lykan Bioscience, a Massachusetts-based contract Manufacturing Services Organization (MSO) and provider of end-to-end solution for cell-based therapies, where he took on the role of chief operating officer (COO) in January. In this podcast,…

Repligen and Navigo target next-wave COVID vaccines with affinity resin

Repligen and Navigo have launched an affinity resin specifically for the purification of COVID-19 vaccines. Last year, bioprocess technology firm Repligen teamed with protein engineering firm Navigo Proteins GmbH to develop an affinity ligand specifically for COVID-19 vaccines. Like many COVID-19 vaccine and therapeutic efforts themselves, the collaboration plus speed of development have borne fruit with the firms launching the NGL COVID-19 Spike Protein Affinity Resin this week. While the handful of COVID-19 vaccines approved so far are not protein-based…

Pfizer cites ‘simplicity’ of mRNA production to overcome COVID-19 variants

Pfizer says it is relatively simple to rejig the formulation and manufacturing infrastructure for its approved mRNA vaccine in the case of COVID-19 variants. Following a year that saw Pfizer bring to the US and Europe the first vaccine against COVID-19, the firm has raised its production targets for 2021 from 1.3 billion doses to 2 billion doses, and expects to deliver 200 million doses to the US by end of May. “Because of the dire need to vaccinate more…

Bioprocessing ‘running hot’ for Danaher with $1.3bn COVID windfall to come

Danaher Corporation reports double-digit sales growth at its bioprocess units Pall and Cytiva, inflated by COVID-related dividends it says will continue this year. For the full year 2020, Danaher Corporation reported net sales of $22.3 billion, a 24.5% increase on the previous year. Life sciences pulled in $10.6 billion of this, up 52% on 2019. While Danaher does not detail its individual business financial figures, the contributions from Cytiva – acquired for $21 billion last April –  and Pall Biotech…

Bio-CDMOs remain in the small molecule game despite divestments

While CDMOs continue to expand biologics and advanced therapy services recent divestments from Lonza and Catalent do not indicate the abandonment of small molecules capabilities. For two of the largest contract development and manufacturing organizations (CDMOs), the new year really did follow the old adage ‘out with the old…’ Catalent began 2021 by agreeing to sell its Blow-Fill-Seal (BFS) sterile contract development and manufacturing business, based at a single site in Woodstock, Illinois, to SK Capital Partners. The CDMO said…

COVID vaccines: Why J&J could have market advantage over others

Tried and tested technologies, a single-dose regimen, and a simple cold-chain infrastructure place Johnson & Johnson’s potential COVID-19 vaccine at an advantage over the current approved offerings. Johnson & Johnson (J&J) has said it plans to present results of its COVID-19 candidate JNJ-78436735, also known as Ad26.COV2-S, recombinant, in the next few days. “Being in the final stages of a robust 45,000-person study, analytics will be completed, and we plan to report out the results by early next week,†CFO…