Author Archives: C. Mölleryd

Scaling Up Clinical T cell Expansion in a Xuriâ„¢ Cell Expansion System

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Administration of antigen-specific T cells (ASTs), in particular for viral infections in transplantation, is one of the key focuses in immunotherapy. The Xuriâ„¢ Cell Expansion System can be used as an alternative to static cell culture methods for the stimulation and expansion of ASTs. The process described here demonstrates the use of the Xuri Cell Expansion System from the initiation of culture to the generation of virus-specific T cells. This includes a semi-static phase for antigen stimulation, a rocking phase…

November 15, 2015

Clinically Relevant T Cells Expanded Using the WAVE Bioreactorâ„¢ 2/10 System

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Lymphocytes, expanded for clinical use, often consist of a small selected starting population, which requires multiple rounds of replication to achieve therapeutic doses. By using perfusion culture with the WAVE Bioreactor 2/10 System, high cell density cultures which are sufficient for therapeutic doses, can be generated. The Cellbagâ„¢ bioreactors, used together with the WAVE system, are functionally closed, single-use bioreactors that are delivered pre-sterilized and suitable for cGMP production. Perfusion is automatically maintained by the WAVE system, which removes metabolites…

November 10, 2014