Fed-batch and perfusion culture are two dominant modes of operation for mammalian-cell-culture based processes. Challenges in the industry (such as competitive products for the same indication or desired cost reductions) are forcing many to explore new production options. Increasingly popular is the application of the ATFâ„¢ System to generate ultra high viable cell concentrations (>100m cells/ml) for a “concentrated†or “intensified†process. The use of the ATF System in a typical concentrated fed-batch process is shown which has generated a…
