Strengthening our position as leaders in the field of molecular biology with expertise in labeling and detection, Enzo Life Sciences now offers the CYTAGâ„¢ TotalCGH Labeling Kit for CGH+SNP arrays.

Array-based Comparative Genomic Hybridization (aCGH) is a well-established method for investigating copy number variations and is used to detect a variety of genomic gains and losses ranging from duplications and deletions, unbalanced translocations, and aneuploidies.  CGH is a robust method to detect chromosomal abnormalities and enables rapid screening of the entire genome.  In addition, single nucleotide polymorphism (SNP), variation at a single nucleotide in a genome, can also be examined on a CGH+SNP array.  A CGH+SNP array enables detection of genomic aberrations associated with copy number variations, but in addition, it can also detect copy neutral aberrations, such as loss of heterozygosity (LOH) and uniparental disomy (UPD), on the same array.

Enzo Life Sciences’ CYTAG™ TotalCGH Labeling Kit contains a complete set of reagents to prepare and label DNA for hybridization to a CGH+SNP array.  The kit is compatible with both CGH arrays and CGH+SNP arrays and includes the CYTAG™ CGH Labeling kit, restriction enzymes AluI and RsaI, and PCR & Gel Clean-up Columns.

Enzo’s well established CYTAG™ CGH Labeling kit is the industry leading DNA labeling kit for CGH arrays.  Our proprietary labeling technology delivers low Derivative Log Ratio (DLR) scores, assuring more confident aberrant calls and fewer failed runs. In addition, the CYTAG™ CGH Labeling kit is compatible with the most common dye-based arrays and has been validated on multiple scanning platforms.

For more information, or to order the CYTAGâ„¢ TotalCGH Labeling Kit or other Enzo Life Sciences products, please visit us at www.enzolifesciences.com or call us at 1-800-942-0430.