Pall’s patented single-pass tangential-flow filtration (TFF) technology simplifies current TFF processes (1). It eliminates the conventional TFF recirculation, allowing an efficient single-pass operation without mixing or foaming issues and exposes the product to low shear, which optimizes the processing of fragile and shear-sensitive molecules. The single-pass feed flow rates are lower than those of conventional TFF, minimizing the hold-up volume and maximizing product recovery. It allows for higher final concentrations because processing limitations due to minimum working volumes are optimized (2–4).

Read the full text of this application note in the PDF (Login required).