Friday, November 19, 2021 Daily Archives

eBook: Cell and Gene Therapies — Optimization Strategies for Processing and Potency

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Although relatively new to the biopharmaceutical industry, cell and gene therapy development and manufacturing are advancing rapidly. At Informa Connect’s September 2021 Cell & Gene Manufacturing & Commercialization Conference and Exhibition, held in Boston and online, presentations reviewed concerns that arise when processing complex therapies and highlighted some innovative strategies for surmounting those obstacles. Most of those approaches described during the event used data-driven solutions, with each step building on the information gained from the previous one. High-throughput technology platforms…

November 19, 2021

Advancing Sterile-Connection Technology for Low-Volume Fluid Transfer

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Biomanufacturers traditionally have relied on laminar-flow hoods or thermal tube welding to establish connections for small-format bioprocesses, including those for cell and gene therapy (CGT) production. But such strategies can introduce processing risks and can pose operational challenges. In October 2021, Troy Ostreng (senior product manager at CPC) described how his company’s MicroCNX sterile connectors could meet biomanufacturers’ needs for low-volume applications. Ostreng’s Presentation Welding tubes and forging open connections under laminar hoods raise several disadvantages for small-format bioprocesses. Processing…

November 19, 2021

COVID drove innovation in consumables sourcing and inventory management

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COVID-19 has changed how drugs and vaccines are made according to experts who say limited raw material supplies and manufacturing capacity have forced industry to innovate in sourcing and inventory management. The pandemic has disrupted the global supply of consumables and technologies according to Josh Speidel from Latham BioPharm Group, who said on BioProcess Insider’s recent State of the Industry webinar that delivery timelines have increased significantly. “The pandemic has put immense pressure on the global manufacturing capacity†adding that…

November 19, 2021