Monday, October 25, 2021 Daily Archives

Using Bio-Layer Interferometry for A Fast and High Precision Influenza Vaccine Potency Assay

by

A fast and accurate determination of vaccine titer during manufacturing is important in understanding vaccine development process performance, and for correctly scaling each process step. The Single Radial Immunodiffusion (SRID) technique has been the most commonly used technique for vaccine titer determination. However, SRID is time consuming and generally exhibits poor precision. An alternative assay that can speed up the analysis process and provide accurate and precise potency data on different vaccine strains is therefore desirable. The Octet® platform’s Bio-Layer…

October 25, 2021

Assessing Your AAV Capsid Content for Product Quality? Get the Confidence You Need with an Automated CE Platform

by

Looking for a hassle-free and rapid analytical method to detect full, partially filled, and empty Adeno-associated virus (AAV) capsids for your gene therapy development? Viral capsid content can impact gene therapy product efficacy and is therefore considered a Critical Quality Attribute (CQA) that must be properly evaluated during the development and manufacturing of AAVs. Traditional analytical tools such as transmission electron microscopy (TEM), analytical ultracentrifugation (AUC), and ion-exchange chromatography (IEX) can be used to characterize capsid content but are complex…

October 25, 2021

Q3: Sartorius says lean manufacturing drives margins

by

Sartorius says its focus on lean manufacturing and creating additional capacity has pushed its margins up, but increased headcount will have an impact going forward. For the first nine months of 2021, German life sciences firm Sartorius reported group sales revenue of €2.6 billion ($3 billion), an increase of 50.4% year-on-year. The firm highlighted strong demand for its bioprocessing services and consumables as a major factor in this growth, with the division contributing almost €2 billon to the top line.…

October 25, 2021

NorthX Biologics takes over Charles River Swedish plant

by

NorthX Biologics will take over Charles River’s manufacturing facility in Matfors, Sweden through $52 million acquisition. Seven months on from Charles River Laboratories $875 million acquisition of Cognate Bio (Cognate acquired Cobra Biologics in November 2019) the firm has offloaded one of its Cognate assets, selling a plant in Matfors, Sweden to private investor group Flerie Invest in an acquisition worth $52 million. The entity has been named North X Biologics and the 7,000 square-meter facility houses process development and…

October 25, 2021

Joint research agreement to develop viral vector tech, says Matica Bio

by

Matica Bio and Sartorius have entered a joint research agreement to develop advanced viral vector manufacturing technology. Matica Biotechnology, a contract development manufacturing organization (CDMO) that specializes in the clinical and commercial production of cell and gene therapies (CGTs), will work on various studies with German life sciences firm Sartorius to streamline and optimize PAT technologies, automation software, and single-use platforms offered by Sartorius for large scale vector production. According to Matica, together both companies will tackle the challenges associated…

October 25, 2021