Tuesday, August 10, 2021 Daily Archives

Evaluate Cell Therapy Product Purity with Aura CL

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The CAR-T development workflow is a multi-step process that includes transfection of T cells with a viral vector to express a chimeric antigen and activation/expansion of the CAR-T using a molecule like a Dynabead conjugated to CD3/CD28. Each of these steps is a potential source of contamination that needs to be removed to ensure the purity of the final cell therapy product. Aura CL™ applies multiple detection methods to facilitate the accurate detection and identification of contaminants in a CAR-T…

August 10, 2021

BeiGene sets sights on US with NJ manufacturing facility

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BeiGene plans to build an R&D and biomanufacturing facility at a 42-acre site in Hopewell, New Jersey. The deal, of which financial details have not been disclosed, sees BeiGene enter into a purchase agreement to acquire a site at the Princeton West Innovation Campus where it will construct a commercial-stage biologic manufacturing and clinical R&D facility. Hopewell’s central location and closeness to a pharmaceutical research, development, and manufacturing talent pool were cited by the firm as reasons to expand its…

August 10, 2021

Appia partners with Kite to develop cell therapies for blood and bone cancers

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Kite will develop CAR-iNKT cells  for the treatment of haematological malignancies using Appia Bio’s ACUA technology platform. The deal, which could be worth up to $875 million, will see Appia responsible for preclinical research of two hematopoietic stem cell (HSC) derived chimeric antigen receptor-engineered invariant natural killer T (CAR-iNKT) product candidates manufactured with CARs provided by Kite. “The core of the partnership is that we will bring together Appia’s cells and Kite’s CARs, putting us right at innovation’s edge.  We…

August 10, 2021

Podcast: GSK’s digital twin approach to vaccine development

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GSK relates its experience of adopting a digital twin technology initiative for its vaccine business on the latest episode of the BioProcess Insider Expression Platform podcast. A digital twin is a virtual representation that serves as the real-time digital counterpart of a physical object or process. Biopharma giant GlaxoSmithKline (GSK) has adopted this technology to advance its vaccine development and manufacturing division. A year after partnering with Siemens and Atos to pilot a digital twin in order to create a…

August 10, 2021