Wednesday, September 30, 2020 Daily Archives

eBook: Viral Vector Purification — A Discussion of Current Challenges and Methods

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Adenoassociated viral (AAV) vectors have become synonymous with gene therapy delivery. However, because they are produced in such small quantities and because their upstream processes carry comparatively large amounts of host-cell DNA and other impurities, AAV purification can be challenging. Several researchers have applied different chromatographic strategies, but no universal method has been adopted in the biopharmaceutical industry. This eBook features a discussion among several industry experts that explores challenges specific to AAV purification, shedding light on whether current strategies…

September 30, 2020

Antibody Internalization: Advanced Flow Cytometry and Live-Cell Analysis Give Rich Insights During Antibody Profiling

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The natural characteristics of antibodies, such as high binding affinity, specificity to a wide variety of targets, and good stability, make them ideal therapeutic candidates for many diseases. Therapeutic antibodies, in particular monoclonal antibodies (mAbs), deliver promising therapeutic results in several different disease areas, such as autoimmunity, oncology, and chronic inflammation. Researchers’ abilities to improve the breadth of antibodies have been aided by innovative technologies for antibody discovery, for instance, through humanization of mouse antibodies and phage display. However, advanced…

September 30, 2020

Using Peptones to Achieve Diverse and Demanding Bioproduction Goals

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As bioproduction requirements advance, it is critical to have consistent, high-quality media and supplements that continue to meet evolving industry needs. Peptones have been successfully used in bioproduction applications for more than 30 years to meet diverse and demanding production requirements. Their unique nutritional profiles and usage flexibility make peptones ideal components for creating a robust bioprocess. This Special Report will demonstrate the benefits of peptones and how they can be used to enhance process performance and consistently yield a…

September 30, 2020

Luina Bio Is Growing Its Service Offerings with New GMP Facility Expansion Plans

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Luina Bio, one of Australia’s most experienced biopharmaceutical contract development and manufacturing organizations, has announced plans to open a new good manufacturing practice (GMP) manufacturing suite. The expansion plans include a new small-scale GMP manufacturing suite that is scheduled to open in the fourth quarter of 2020. The suite will complete the company’s service offerings to customers that require small-scale GMP facilities. “This new suite will allow us to respond to those customers that need a smaller active dose for…

September 30, 2020

Guangzhou campus opens doors for bioprocess training

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With support from Ireland’s NIBRT and bioprocess vendor Cytiva, the Guangzhou Bioprocess Academy has begun training the next generation of biopharma talent in China. In December 2019, this publication reported that a combined $10 million investment from bioprocess vendor Cytiva (then known as GE Healthcare Life Sciences) and Guangzhou Development District government was being used to establish a biomanufacturing training center in the Guangdong province in China. Ten months on and the center, known as the Guangzhou Bioprocess Academy, has…

September 30, 2020

Novavax and J&J ink COVID-19 vaccine fill/finish deals

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To support their COVID-19 vaccine candidates, Novavax has secured space at Endo’s facility and Johnson & Johnson has struck a deal with Grand River Aseptic Manufacturing (GRAM). As Novavax progresses its COVID-19 vaccine candidate through the clinic, the firm has inked numerous deals with contract development and manufacturing organizations (CDMOs) to ensure it will be ready for large-scale production. The latest focuses on the fill and finish of the Phase II candidate, NVX-CoV2373, with a deal in place with Par…

September 30, 2020