Friday, November 5, 2010 Daily Archives

Critical aspects for mixing of stratified solutions in vertical bags

by

With increasing use of single-use, disposable fluid processing systems, concerns of mixing arise in processes such as protein concentration, clarification and diafiltration. For some operating conditions of flow rate, solution viscosity or flow path configurations, protein solutions may become stratified in vertically-oriented hanging bags. This can cause decreased efficiency in cross flow applications. In this study, we modeled a stratified solution and tested the influence of these various operating conditions using ReadyCircuit* 2-D pillow bags. Even with viscous materials, flow…

November 5, 2010

Optical Oxygen and pH Sensors for Monitoring Biofermentation Processes

by

Advances in high-performance sensor materials and optoelectronics have enabled optical sensors for use in markets including the life sciences, environmental, food and beverage, process control and biotechnology. Compared with traditional electrochemical sensing techniques such as galvanic, paramagnetic and fuel cell sensors, these optical sensors can be made in small and customizable form factors such as probes and self-adhesive patches. The sensors also have fast response, provide long-term stability and are chemically inert. This experiment demonstrates the viability of optical sensors…

November 5, 2010